Taking the Complication out of Chemotherapy by Dr. Maxwell M. Krem
Dr. Krem presents this lecture by first describing chemotherapy indications and which patients should receive chemotherapy. He then explains common toxicities and their treatments along with drug-specific toxicities.
'Chemotherapy and Complications' Notes
In this lecture, Dr. Krem gives an overview on the options for chemotherapy and how to manage complications arising from its use. The lecture walks us through the vital aspects of patient selection and routes of administration but also focuses specifically on the various toxicities using a case based approach. While chemotherapy is a vast subject, as internists it is important to recognize the ways to deal with the most commonly seen adverse effects.
- Not all patients are suited to withstand chemotherapy
- Some adverse effects from chemotherapy can be anticipated and pre-treated
- Thinking through the mechanism of toxicity allows one to tailor pharmacotherapy effectively
- Drugs used to treat toxicity can precipitate their own toxicities
- Intent of chemotherapy
- Patient selection
- Routes of delivery
o Hypersensitivity reactions
o Tumor lysis syndrome
o Cancer related anemia
o Neutropenic fever
- Agent specific toxicities: Platins, vincristine, anthracyclines
1. McQuade RM, Stojanovska V, Abalo R, Bornstein JC, Nurgali K. Chemotherapy-Induced Constipation and Diarrhea: Pathophysiology, Current and Emerging Treatments. Front Pharmacol. 2016 Nov 3;7:414. eCollection 2016.
Dr. Maxwell M. Krem, MD, Ph.D.
Dr. Maxwell Krem is a medical oncologist who sees patients with hematologic malignancies at James Graham Brown Cancer Center (JGBCC), University of Louisville School of Medicine. His primary specialty is bone marrow transplantation. Dr. Krem recalls an experience he had as a young person when his grandfather had cancer. “I saw a lack of bedside manner and a lack of sensitivity,” he says, adding “It really made a big impression on me... I knew I could do better so I’ve tried to develop a humanistic approach in my rapport with patients and their families. I try to be a source of support, whatever the outcome.”
In this presentation, Dr. Betty Villafuerte discusses complications-based approaches to guide treatment modality of obesity. She them reviews treatment guidelines on lifestyle modifications and the use of pharmacotherapy in managing obesity. Finally, she examines the role of meal frequency, meal timing, lifestyle behavior, and intelligence on obesity.
In this presentation, Dr. Hugh Shoff presents Healthcare Quality and Safety by first explaining its history and importance. He then discusses the goals of physicians and how they can achieve those goals through patient safety as well as quality improvement and methods. After, he concludes with a case example.
Out for Lunch!
We hope you've enjoyed our lectures from the academic year 2016-17. We will be taking a short break from posting in order to keep our lectures fresh and relevant. See you in two weeks!
In Controlling Multi-Drug Resistant Bacteria in the Healthcare Setting: The Role of the Hospital Epidemiologist with Dr. Forest W. Arnold, Dr. Arnold covers the MDR control program as well as strategies to prevent and manage MDR.
The July Effect: residents around the world are beginning their residencies this month, giving many to believe there will be more mistakes made in the hospital. Not to worry! Louisville Lectures has a variety of presentations given by physicians, psychiatrists, and fellow residents here to help you transition seamlessly as well as restore your confidence. You got this!
Check out last year's Boot Camp where the Louisville Lectures team highlights some of our most-viewed lectures. Our Boot Camp covered a series of high-yield, critical topics that are useful to starting interns. For more recent lectures, visit our IMLS Home Page.
Dear Friends and Colleagues,
We here at Louisville Lectures are excited to share a new project with you that has been nearly two years in the making. When working with our incoming residents on procedure training, we noted that there were no resources that fit our needs precisely. We set about trying to define what the ideal training resource would look like. This included a first person perspective because, as everyone says, there is simply no substitute for seeing (and doing) it for yourself. We have attempted to give learners an opportunity to just this in the first installment of our Procedure Series. The production of this series with a GoPro Dual Hero allows us to also provide an optional 3D experience to allow for the viewer to perceive the depth of field that can be experienced in few other ways.
I hope that you will find the Procedure Series as interesting and as much of a learning experience as we have. It could not have been done without the expertise and hard work of our team. We have a great deal more to follow this, as I have dedicated a portion of my Chief year here at Louisville to obtain similar perspectives of several other procedures. As I step back from my role as Managing Director to pursue a fellowship in Pulmonary and Critical Care Medicine, Drs. Laura Bishop and Christopher Migliore will be stepping forward to help manage the long-term growth of Louisville Lectures and continuation of our current projects. I look forward to seeing even more of the impact their leadership will have on Louisville Lectures.
Michael J. Burk, M.D.
Louisville Lectures creatorDr. Michael Burk presents "Breaking Bad News and Difficult Decisions" to emphasize the importance of thinking carefully before delivering "bad news" to patients. With the use of case reports and group discussions, Dr. Burk explains how physicians can use empathy, patience, and planning, be the most effective and kind during these difficult discussions.
In this lecture, Dr. El-Kersh discusses the classification of Pulmonary Hypertension as well as the definition of Pulmonary Arterial Hypertension. He then discusses the pathophysiology, pathology, diagnosis, treatment and prognosis of Pulmonary Arterial Hypertension.
Dr. Eric Burton explains brain tumors in this presentation about CNS tumors, common gliomas, histological classification of tumors and the epidemiolgy of primary brain and CNS tumors. He also discusses the general signs and symptoms of increased intracranial pressure as well as focal cerebral syndromes. After presenting various treatment plans, Dr. Burton talks through survival rates along with how to speak with patients about expected timelines.
Dr. Martin Brown presents ALS and other motor neuron diseases by first reviewing their history and clinical course. He then discusses the diagnostic workup and efforts to find anything instead of ALS and finally ends his presentation with a discussion on the standard of care and the multidisciplinary ALS clinic.