Taking the Complication out of Chemotherapy by Dr. Maxwell M. Krem
Dr. Krem presents this lecture by first describing chemotherapy indications and which patients should receive chemotherapy. He then explains common toxicities and their treatments along with drug-specific toxicities.
'Chemotherapy and Complications' Notes
In this lecture, Dr. Krem gives an overview on the options for chemotherapy and how to manage complications arising from its use. The lecture walks us through the vital aspects of patient selection and routes of administration but also focuses specifically on the various toxicities using a case based approach. While chemotherapy is a vast subject, as internists it is important to recognize the ways to deal with the most commonly seen adverse effects.
- Not all patients are suited to withstand chemotherapy
- Some adverse effects from chemotherapy can be anticipated and pre-treated
- Thinking through the mechanism of toxicity allows one to tailor pharmacotherapy effectively
- Drugs used to treat toxicity can precipitate their own toxicities
- Intent of chemotherapy
- Patient selection
- Routes of delivery
o Hypersensitivity reactions
o Tumor lysis syndrome
o Cancer related anemia
o Neutropenic fever
- Agent specific toxicities: Platins, vincristine, anthracyclines
1. McQuade RM, Stojanovska V, Abalo R, Bornstein JC, Nurgali K. Chemotherapy-Induced Constipation and Diarrhea: Pathophysiology, Current and Emerging Treatments. Front Pharmacol. 2016 Nov 3;7:414. eCollection 2016.
Dr. Maxwell M. Krem, MD, Ph.D.
Dr. Maxwell Krem is a medical oncologist who sees patients with hematologic malignancies at James Graham Brown Cancer Center (JGBCC), University of Louisville School of Medicine. His primary specialty is bone marrow transplantation. Dr. Krem recalls an experience he had as a young person when his grandfather had cancer. “I saw a lack of bedside manner and a lack of sensitivity,” he says, adding “It really made a big impression on me... I knew I could do better so I’ve tried to develop a humanistic approach in my rapport with patients and their families. I try to be a source of support, whatever the outcome.”
Dr. Patrick McKenzie identifies and briefly explains key areas of outpatient medicine. He then highlights aspects of outpatient medicine that are highly testable. Throughout his talk, he discusses statistics, immunizations, screening, cough, dizziness, hearing loss and tinnitus, MSK pain, dyslipidemia, obesity, and depression.
Dr. Hala Karnib presents Ventilation 101 by defining oxygenation versus ventilation, non-invasive positive pressure ventilation, and mechanical ventilation. With NIPPV, Dr. Karnib discusses indications/ contraindications, equipment, and settings. She then describes indications, modes of mechanical ventilation, and trouble shooting for mechanical ventilation.
Happy Holidays! It's almost 2018 and we couldn't be more excited to kick 2017 to the curb and send it to outpatient care. Watch our most watched outpatient care lectures to ensure 2017 is given the same treatment as 2008.
In this Presentation Dr. Boris D. Lushniak discusses the core public health functions: assessment and monitoring of the health of communities and populations at risk, the formulation of public policies, and to assure that all populations have access to appropriate and cost-effective care. Keeping these functions relavent throughout his talk, Dr. Lushniak discusses various skin cancers and conditions. He then concludes his presentation explaining how dermatology fits into the public health model.
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Dr. Stephen J. Winters discusses "hypogonadism" in women and men through various photos, studies, and cases. He uses many case questions to discuss different scenarios as well as characteristics of hypogonadism that may not be obvious at first glance.
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This week Louisville Lectures will be taking a break. You should too - but you can't! Here are a couple of lectures that could be useful for this upcoming season:
Dr. Hiram Rivas Perez presents Asthma by discussing the definition, prevalence, risk of developing asthma, and diagnosis. He then goes on to discuss the history of asthma as well as diagnostic testing. After, he presents different treatments along with various cases as examples.
In this presentation, Dr. Karim El-Kersh discusses the definition, physiology, and risk factors of Obstructive Sleep Apnea. He then discusses diagnosis, consequences, and lastly, treatment.