Walk into any ICU on any given day and there will be a patient who is suffering from sepsis. Arguably, the most common diagnosis that the ICU physician encounters and a diagnosis that requires rapid recognition and treatment. ICU physicians have been trained to follow surviving sepsis guidelines which have gone through updates over the years since their first launch in 2002. We now have the 2021 updates, and I would like to go over some of those most important updates with you. Hopefully this will be informative and save you from having to read a 60 page document.