Dr. Cindy Owen gives an overview of cutaneous drug reactions and an approach to diagnosis and treatment in this image-driven lecture. She spends time on urticaria, fixed drug eruption, serum-sickness reaction, hypersensitivity vasculitis, morbilliform rash, drug reaction with eosinophilia and systemic symptoms, erythema multiforme, toxic epidermal necrolysis and less familiar drug reactions (acute generalized exanthematous pustulosis, symmetric drug related intertriginous and flexural exanthem).